The mRS scores after treatment (1.7??1.7, mean??SD) were significantly decreased compared with those before treatment (4.2??0.9) in the 13 treated patients (P?P?Tmem1 symptoms included hallucinations, delusions, mood changes, agitation, and abnormal behavior. All seizures observed in the patients were generalized convulsions. Involuntary movements and respiratory impairment were rare (14% and 7%, respectively). Interestingly, the frequencies of consciousness disturbance and seizures were significantly higher in the acute-onset group (100% and 75%, respectively) than in the subacute-onset group (33% and 0%, respectively) (P?P?=?0.10 and <0.05, respectively). These findings suggest that symptoms of LE associated with anti-NAE antibodies are not uniform and may differ depending on onset type. Regarding thyroid function, all 14 patients were clinically euthyroid except for 1 patient with low T4 who presented with no symptoms related to hypothyroidism. Hyponatremia, defined as a serum Xanthopterin (hydrate) sodium concentration of less than 135?mEq/L, which is frequently observed in LE associated with anti-LGI1 antibodies, was observed in Xanthopterin (hydrate) 6 (43%) patients at admission (Table ?(Table2).2). When the CSF was examined, some type of abnormality was observed in 12 of 13 patients (92%). The cell counts and protein concentrations in the CSF ranged from.