Henrik OSTER


Address: Institute of Neurobiology

                University of Lübeck

                Ratzeburger Allee 160

                23562 Lübeck, Germany

Email: henrik.oster@uni-luebeck.de

 

Web: http://www.neurobio.uni-luebeck.de/

 

Career:

1992-9 Studies in biochemistry, biophysical chemistry and pharmacology at the University of Hannover and Hannover Medical School (MHH), DE.

2003 PhD in biochemistry in the lab of Urs Albrecht, University of Fribourg, CH; thesis title: Interaction of Per and Cry genes in the mammalian circadian clock.

2002-6 Postdoctoral stays in the labs of Michael Leitges (PKC signaling) and Gregor Eichele (non-SCN clocks), Max Planck Institute for experimental Endocrinology Hannover, DE.

2006-7 Postdoctoral stay in the lab of Russell G. Foster (non-visual photoreception), Oxford University, UK

2007-12 Emmy Noether junior group leader at the Max Planck Institute for biophysical Chemistry Göttingen, DE (2007-12).

2012 Habiliation in biochemistry, Göttingen University Medical School (UMG), DE; thesis title: Synchronisationsmechanismen des zirkadianen Systems der Maus.

2011-16 Lichtenberg Professor of Chronophysiology, University of Lübeck, DE

2017- Professor of Neurobiology and director, Institute of Neurobiology, University of Lübeck, DE

 

Prizes:

2002 Faculty Prize, University of Fribourg, CH

2003 Otto Hahn Medal, Max Planck Society, DE

2007 Emmy Noether Fellowship, German Research Foundation (DFG), DE

2011 Lichtenberg Fellowship, Volkswagen Foundation, DE

2014 Hansa Prize for Psychiatry, University of Rostock, DE

 

Editorial board memberships: Journal of Circadian Rhythms, BioMed Research International, PLoS One, Journal of Exercise Rehabilitation, Nature Scientific Reports, Endocrine Connections

 

Scientific society memberships: Society for the Research on Biological Rhythms, European Biological Rhythms Society, German Society for Endocrinology, German Physiological Society, American Physiological Society

 

Main research interests: my lab analyzes the mechanisms that drive circadian rhythms of physiology and behavior in mammals. Specifically, we study the interaction of circadian clocks in different tissues and how clock time is translated into physiological functions – in cells, mice, and humans.

 

Selected publications (overall 78 entries in PubMed; Hirsh index 33):

  1. Lymphocyte Circadian Clocks Control Lymph Node Trafficking and Adaptive Immune Responses. Druzd D, Matveeva O, Ince L, Harrison U, He W, Schmal C, Herzel H, Tsang AH, Kawakami N, Leliavski A, Uhl O, Yao L, Sander LE, Chen CS, Kraus K, de Juan A, Hergenhan SM, Ehlers M, Koletzko B, Haas R, Solbach W, Oster H, Scheiermann C. Immunity. 2017 Jan 17;46(1):120-132.
  2. The functional and clinical significance of the 24-h rhythm of circulating glucocorticoids. Oster H, Challet E, Ott V, Arvat E, de Kloet ER, Dijk DJ, Lightman S, Vgontzas A, Van Cauter E. Endocr Rev. 2016 Oct 17:er20151080.
  3. Adrenal glucocorticoids have a key role in circadian resynchronization in a mouse model of jet lag. Kiessling S, Eichele G, Oster H. J Clin Invest. 2010 Jul;120(7):2600-9.
  4. The acute light-induction of sleep is mediated by OPN4-based photoreception. Lupi D*, Oster H*, Thompson S, Foster RG. Nat Neurosci. 2008 Sep;11(9):1068-73.
  5. Microarray analysis and functional genomics identify novel components of melanopsin signaling. Peirson SN*, Oster H*, Jones SL, Leitges M, Hankins MW, Foster RG. Curr Biol. 2007 Aug 21;17(16):1363-72.
  6. Light entrainment of the mammalian circadian clock by a PRKCA-dependent posttranslational mechanism. Jakubcakova V*, Oster H*, Tamanini F, Cadenas C, Leitges M, van der Horst GT, Eichele G. Neuron. 2007 Jun 7;54(5):831-43.
  7. The circadian rhythm of glucocorticoids is regulated by a gating mechanism residing in the adrenal cortical clock. Oster H, Damerow S, Kiessling S, Jakubcakova V, Abraham D, Tian J, Hoffmann MW, Eichele G. Cell Metab. 2006 Aug;4(2):163-73.
  8. Abnormal development of the locus coeruleus in Ear2(Nr2f6)-deficient mice impairs the functionality of the forebrain clock and affects nociception. Warnecke M, Oster H, Revelli JP, Alvarez-Bolado G, Eichele G. Genes Dev. 2005 Mar 1;19(5):614-25.
  9. Loss of circadian rhythmicity in aging mPer1-/-mCry2-/- mutant mice. Oster H, Baeriswyl S, Van Der Horst GT, Albrecht U. Genes Dev. 2003 Jun 1;17(11):1366-79.
  10. Oster H, Yasui A, van der Horst GT, Albrecht U. Disruption of mCry2 restores circadian rhythmicity in mPer2 mutant mice. Genes Dev. 2002 Oct 15;16(20):2633-8. * authors contributed equally