Lars GEFFERS


Web:

http://www.parkinson.lu

 Career:

1995-1999            Studies in cell biology, genetics and botany at the Technical University of Braunschweig, Germany

2000-2001            Diploma in biochemistry in the lab of John McCarthy, University of Manchester Institute of Science and Technology (UMIST), UK; thesis title: Characterization of Novel Components of the eIF4F Complex in Schizosaccharomyces pombe

2001-2005            Doctorate in biochemistry at the Leibniz University Hanover in the lab of Karl Bauer, Max Planck Institute for Experimental Endocrinology, Hanover, DE; thesis title: Generation and analysis of a mouse with targeted inactivation of the TRH-DE gene

2005-2015            Postdoctoral phase in the lab of Gregor Eichele, Max Planck Institute for Biophysical Chemistry, Göttingen, DE; main projects: EURExpress, EuReGene, METscout, and Genepaint

2015-                     Project Manager for NCER-PD at the Luxembourg Centre for Systems Biomedicine, University of Luxembourg, LU

 

Prizes:

1999                       ZSB Prize in genetics, Technical University of Braunschweig, DE

 

Scientific society memberships: International Society for Biocuration

Main professional interest:  The NCER-PD Programme pursues an integrative systems biomedicine approach, encompassing clinical, neuroanatomical and molecular characterisation, in order to identify and explain the mechanisms of PD pathogenesis and heterogeneity. In this context, human metabolic reconstructions and disease maps serve as a basis for novel modelling strategies at systems level.

 

 Selected publications (overall 13 entries in PubMed; Hirsh index 9): 

  1. Geffers L, Tetzlaff B, Cui X, Yan J, Eichele G. METscout: a pathfinder exploring the landscape of metabolites, enzymes and transporters. Nucleic Acids Res. 2013 Jan;41(Database issue):D1047-54. 
  2. Geffers L, Herrmann B, Eichele G. Web-based digital gene expression atlases for the mouse. Mamm Genome. 2012 Oct;23(9-10):525-38. 
  3. Diez-Roux G, Banfi S, Sultan M, Geffers L , Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011 Jan 18;9(1):e1000582. 
  4. Santagata S, Maire CL, Idbaih A, Geffers L, Correll M, Holton K, Quackenbush J, Ligon KL. CRX is a diagnostic marker of retinal and pineal lineage tumors. PLoS One. 2009 Nov 20;4(11):e7932. 
  5. Raciti D, Reggiani L, Geffers L, Jiang Q, Bacchion F, Subrizi AE, Clements D, Tindal C, Davidson DR, Kaissling B, Brändli AW. Organization of the pronephric kidney revealed by large-scale gene expression mapping. Genome Biol. 2008;9(5):R84. 

 

Book Chapter

Geffers L, Eichele G. High-Throughput In Situ Hybridization: Systematical Production of Gene Expression Data and Beyond. In: In Situ Hybridization Methods.Vol 99. Neuromethods.; 2015:221-245. doi:10.1007/978-1-4939-2303-8_11.